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Caution in cvd, asthma, hepatic impairment, peptic ulcer, respiratory impairment; the impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives hypnotics including barbiturates , narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; avoid use of promethazine hcl and codeine phosphate oral solution in patients on these medications anaphylaxis in susceptible individuals may impair ability to drive or perform hazardous tasks monitor closely with cardiovascular disease, hepatic impairment, reye syndrome, history of sleep apnea depresses hypothalamic thermoregulatory mechanism; exposure to extreme temperatures may cause hypo- or hyperthermia antiemetic effect may obscure toxicity of chemotherapeutic drugs concomitant use of opioids, including promethazine hcl and codeine cholestoplex sale phosphate oral solution, with benzodiazepines, or other cns depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death; avoid use of opioid cough medications in patients taking benzodiazepines, other cns depressants, or alcohol convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients; promethazine may lower seizure threshold; it should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold promethazine is a phenothiazine; phenothiazines are associated with dystonic reactions; in pediatric patients who are acutely ill associated with dehydration, there is increased susceptibility to dystonias with promethazine hcl use the respiratory-depressant effects of narcotic analgesics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in presence of head injury, intracranial lesions, or a pre-existing increase in intracranial pressure; narcotics may produce adverse reactions which may obscure clinical course of patients with head injuries a potentially fatal symptom complex sometimes referred to as neuroleptic malignant syndrome nms reported in association with promethazine hcl alone or in combination with antipsychotic drugs; 1 management of nms should include immediate discontinuation of promethazine hcl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available promethazine should be used with caution in patients with bone-marrow depression; leukopenia and agranulocytosis reported, usually when promethazine hcl has been used in association with other known marrow-toxic agents.

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Posted: 03月 15th, 2018
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